Isaac Sachs is a flirtatious, heavy-drinking scientist who used to work with Rufus Sixsmith. After Rufus’s death, Luisa Rey tells Isaac she thinks someone murdered Rufus, and ultimately Isaac agrees to betray his bosses by collaborating with Luisa. He gets killed, possibly just as collateral damage, during the same jet explosion that kills Grimaldi. Isaac’s life highlights the dangers of trying to tell the truth and go against people in power.