Romantic writers portrayed nature as the greatest and most perfect force in the universe. They used words like "sublime" (as Mary Shelley herself does in describing Mont Blanc in Frankenstein) to convey the unfathomable power and flawlessness of the natural world. In contrast, Victor describes people as "half made up." The implication is clear: human beings, weighed down by petty concerns and countless flaws such as vanity and prejudice, pale in comparison to nature's perfection.
It should come as no surprise, then, that crises and suffering result when, in Frankenstein, imperfect men disturb nature's perfection. Victor in his pride attempts to discover the "mysteries of creation," to "pioneer a new way" by penetrating the "citadel of nature." But just as a wave will take down even the strongest swimmer, nature prevails in the end and Victor is destroyed for his misguided attempt to manipulate its power.